MIAMI — Dolphins quarterback Tua Tagovailoa was carted off to the locker room with a rib injury after taking a hit from Buffalo Bills defensive end AJ Epenesa during Miami’s second drive of Sunday’s game.

The Dolphins later ruled him out for the game.

On fourth-and-1, Epenesa blew past Dolphins right tackle Jesse Davis and hit Tagovailoa as he threw a pass. The ball fell incomplete, and Tagovailoa was slow to get up before trying to leave the field.

He collapsed to the ground before he got to the Dolphins sideline, however, and was attended to by trainers before walking gingerly to the sideline. Tagovailoa briefly sat on the bench before being carted to the locker room. Jacoby Brissett entered the game in his stead.

Buffalo sacked Tagovailoa three times before his injury.

Brissett finished 24 of 40 passing for 169 yards and an interception in the Dolphins’ 35-0 loss.